Separation of Sedative – Hypnotic Drugs with Mixed Micellar Liquid Chromatography
Authors
Abstract:
Separation of ten sedative- hypnotic drugs was performed by RP-HPLC using mixed micellar mobile phase. Effect of temperature, type and amount of organic modifier in mobile phase on efficiency (N) and asymmetry factor (B/A) showed that, the appropriate conditions for a good separation were 35°C and 7% (V/V) butanol in mobile phase. Variations of selectivity factor versus butanol concentration, Mixture of SDS/ Brij- 35 concentrations and pH of mobile phase showed that the appropriate conditions were 7%(V/V), 15 mM SDS +1.0mM Brij-35 and pH=3 in mobile phase respectively.
similar resources
separation of sedative – hypnotic drugs with mixed micellar liquid chromatography
separation of ten sedative- hypnotic drugs was performed by rp-hplc using mixed micellar mobile phase. effect of temperature, type and amount of organic modifier in mobile phase on efficiency (n) and asymmetry factor (b/a) showed that, the appropriate conditions for a good separation were 35°c and 7% (v/v) butanol in mobile phase. variations of selectivity factor versus butanol concentration, ...
full textSEPARATION OF POLYCYCLIC AROMATIC HYDROCARBONS WITH MIXED MICELLAR HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
Separation of Polycyclic Aromatic Hydrocarbons was performed by RP-HPLC using mixed micellar mobile phase. Effect of temperature, types and amounts of coorganic solvent in mobile phase on efficiency, asymmetry factor and selectivity factor showed that the appropriate condition for separation of these compounds was 3% isopropanol (V/V) as co-organic solvent in mobile phase at 40°C. Analysis of...
full textSeparation of Biojenic Amines Using Dansyl Cloride Derivatization and Mixed Micellar Liquid Chromatography
Separation of some biogenic amines via RP-HPLC using mixed micellar mobile phase was investigated. The compounds were derivatized before hand by dansyl chloride as a chromophoric reagent. Appropriate conditions for separation, were determined by studying factors such as temperature, type and percentage of organic modifier, concentration of surfactants (SDS and Brij-35) and the pH of the mob...
full textseparation of polycyclic aromatic hydrocarbons with mixed micellar high performance liquid chromatography
separation of polycyclic aromatic hydrocarbons was performed by rp-hplc using mixed micellar mobile phase. effect of temperature, types and amounts of coorganic solvent in mobile phase on efficiency, asymmetry factor and selectivity factor showed that the appropriate condition for separation of these compounds was 3% isopropanol (v/v) as co-organic solvent in mobile phase at 40°c. analysis of t...
full textSedative-Hypnotic and Anxiolytic Drugs
The primary use of sedative–hypnotic and anxiolytic drugs is to encourage calmness (anxiolytics or sedatives) or to produce sleep (sedative–hypnotics). All people are subject to states of emotional tension and uneasiness. For otherwise healthy individuals, these occasions are usually sufficiently mild and short that pharmacological intervention is unnecessary. However, at times the symptoms of ...
full textseparation of biojenic amines using dansyl cloride derivatization and mixed micellar liquid chromatography
separation of some biogenic amines via rp-hplc using mixed micellar mobile phase was investigated. the compounds were derivatized before hand by dansyl chloride as a chromophoric reagent. appropriate conditions for separation, were determined by studying factors such as temperature, type and percentage of organic modifier, concentration of surfactants (sds and brij-35) and the ph of the mobile ...
full textMy Resources
Journal title
volume 24 issue 2
pages 59- 63
publication date 2005-06-01
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023